It has been almost 150 years since Dr Langdon Down first brought to our attention people with Down syndrome. Life expectancy, level of intellectual functioning, physical health, psychological health, social functioning, and integration into society are all issues that have markedly changed since 1866. The matter of ageing in people with Down syndrome has consistently remained an area of intense interest. This book documents the most important published literature on the issue of dementia and Down syndrome published since Dr Langdon Down's momentous paper. Further, a number of publications from the general population which have had significant impact in the field of dementia and Down syndrome, and a number of papers in young adults and children with Down syndrome that have important implications for the ageing population have been included.
The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection.
Stepmothers, do you often feel awkward and excluded when spending time with your husband and your stepdaughter? Does their physical affection seem excessive or inappropriate? Do you feel she is more like the "other woman" than your stepdaughter? If the answer to these questions and more is a resounding YES, then you might have a Mini-Wife in your marriage. Mini-Wife Syndrome is more common than most people realize in relationships where single fathers have inadvertently allowed their daughters to step into roles of companion, confidante, and/or helpmate with their fathers. In this book, we discuss Mini-Wife Syndrome from start to finish... the symptoms, the causes, complications, and possible treatments to control this disease that can and will wreck your relationship
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